IFI16 is an innate immune sensor for intracellular DNA

The detection of intracellular microbial DNA is critical to an appropriate innate immune response, however current knowledge on how such DNA is sensed is limited. Here we identify IFI16, a PYHIN protein, as an intracellular DNA sensor mediating interferon-β (IFNβ)-induction. IFI16 directly associate...

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Detalhes bibliográficos
Main Authors: Unterholzner, Leonie, Keating, Sinead E., Baran, Marcin, Horan, Kristy A., Jensen, Søren B., Sharma, Shruti, Sirois, Cherilyn M., Jin, Tengchuan, Xiao, Tsan, Fitzgerald, Katherine A., Paludan, Søren R., Bowie, Andrew G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3142795/
https://ncbi.nlm.nih.gov/pubmed/20890285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1932
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