IFI16 is an innate immune sensor for intracellular DNA

The detection of intracellular microbial DNA is critical to an appropriate innate immune response, however current knowledge on how such DNA is sensed is limited. Here we identify IFI16, a PYHIN protein, as an intracellular DNA sensor mediating interferon-β (IFNβ)-induction. IFI16 directly associate...

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Main Authors: Unterholzner, Leonie, Keating, Sinead E., Baran, Marcin, Horan, Kristy A., Jensen, Søren B., Sharma, Shruti, Sirois, Cherilyn M., Jin, Tengchuan, Xiao, Tsan, Fitzgerald, Katherine A., Paludan, Søren R., Bowie, Andrew G.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3142795/
https://ncbi.nlm.nih.gov/pubmed/20890285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1932
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