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The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells
The recognition of pathogenic DNA is important to the initiation of antiviral responses. Here we report the identification of DDX41, a member of the DEXDc family of helicases, as an intracellular DNA sensor in myeloid dendritic cells (mDCs). Knockdown of DDX41 expression by short hairpin RNA blocked...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3671854/ https://ncbi.nlm.nih.gov/pubmed/21892174 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2091 |
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