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The DEAH box RNA helicase DHX33 senses cytosolic RNA and activates the NLRP3 inflammasome
The NLRP3 inflammasome plays a major role in innate immune responses by activating caspase-1, resulting in secretion of interleukin (IL)-18 and IL-1β. Although cytosolic double-stranded RNA (dsRNA) and bacterial RNA are known to activate the NLRP3 inflammasome, the upstream sensor is unknown. We inv...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3756931/ https://ncbi.nlm.nih.gov/pubmed/23871209 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2013.07.001 |
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