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The DEAH box RNA helicase DHX33 senses cytosolic RNA and activates the NLRP3 inflammasome
The NLRP3 inflammasome plays a major role in innate immune responses by activating caspase-1, resulting in secretion of interleukin (IL)-18 and IL-1β. Although cytosolic double-stranded RNA (dsRNA) and bacterial RNA are known to activate the NLRP3 inflammasome, the upstream sensor is unknown. We inv...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3756931/ https://ncbi.nlm.nih.gov/pubmed/23871209 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2013.07.001 |
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