The DEAH box RNA helicase DHX33 senses cytosolic RNA and activates the NLRP3 inflammasome

The NLRP3 inflammasome plays a major role in innate immune responses by activating caspase-1, resulting in secretion of interleukin (IL)-18 and IL-1β. Although cytosolic double-stranded RNA (dsRNA) and bacterial RNA are known to activate the NLRP3 inflammasome, the upstream sensor is unknown. We inv...

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Bibliographic Details
Main Authors: Mitoma, Hiroki, Hanabuchi, Shino, Kim, Taeil, Bao, Musheng, Zhang, Zhiqiang, Sugimoto, Naoshi, Liu, Yong-Jun
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3756931/
https://ncbi.nlm.nih.gov/pubmed/23871209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2013.07.001
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