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The role of cytochrome P450 enzymes in carcinogen activation and detoxication: an in vivo–in vitro paradox
Many chemical carcinogens require metabolic activation via xenobiotic-metabolizing enzymes in order to exert their genotoxic effects. Evidence from numerous in-vitro studies, utilizing reconstituted systems, microsomal fractions and cultured cells, implicates cytochrome P450 enzymes as being the pre...
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| Publicado no: | Carcinogenesis |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6124610/ https://ncbi.nlm.nih.gov/pubmed/29726902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgy058 |
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