TLR4-dependent fibroblast activation drives persistent organ fibrosis in skin and lung

Persistent fibrosis in multiple organs is the hallmark of systemic sclerosis (SSc). Recent genetic and genomic studies implicate TLRs and their damage-associated molecular pattern (DAMP) endogenous ligands in fibrosis. To test the hypothesis that TLR4 and its coreceptor myeloid differentiation 2 (MD...

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Bibliografski detalji
Izdano u:JCI Insight
Glavni autori: Bhattacharyya, Swati, Wang, Wenxia, Qin, Wenyi, Cheng, Kui, Coulup, Sara, Chavez, Sherry, Jiang, Shuangshang, Raparia, Kirtee, De Almeida, Lucia Maria V., Stehlik, Christian, Tamaki, Zenshiro, Yin, Hang, Varga, John
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2018
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124522/
https://ncbi.nlm.nih.gov/pubmed/29997297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.98850
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