TLR4-dependent fibroblast activation drives persistent organ fibrosis in skin and lung

Persistent fibrosis in multiple organs is the hallmark of systemic sclerosis (SSc). Recent genetic and genomic studies implicate TLRs and their damage-associated molecular pattern (DAMP) endogenous ligands in fibrosis. To test the hypothesis that TLR4 and its coreceptor myeloid differentiation 2 (MD...

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Enregistré dans:
Détails bibliographiques
Publié dans:JCI Insight
Auteurs principaux: Bhattacharyya, Swati, Wang, Wenxia, Qin, Wenyi, Cheng, Kui, Coulup, Sara, Chavez, Sherry, Jiang, Shuangshang, Raparia, Kirtee, De Almeida, Lucia Maria V., Stehlik, Christian, Tamaki, Zenshiro, Yin, Hang, Varga, John
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124522/
https://ncbi.nlm.nih.gov/pubmed/29997297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.98850
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