TLR4-dependent fibroblast activation drives persistent organ fibrosis in skin and lung

Persistent fibrosis in multiple organs is the hallmark of systemic sclerosis (SSc). Recent genetic and genomic studies implicate TLRs and their damage-associated molecular pattern (DAMP) endogenous ligands in fibrosis. To test the hypothesis that TLR4 and its coreceptor myeloid differentiation 2 (MD...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:JCI Insight
मुख्य लेखकों: Bhattacharyya, Swati, Wang, Wenxia, Qin, Wenyi, Cheng, Kui, Coulup, Sara, Chavez, Sherry, Jiang, Shuangshang, Raparia, Kirtee, De Almeida, Lucia Maria V., Stehlik, Christian, Tamaki, Zenshiro, Yin, Hang, Varga, John
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Clinical Investigation 2018
विषय:
Research Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124522/
https://ncbi.nlm.nih.gov/pubmed/29997297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.98850
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