TLR4-dependent fibroblast activation drives persistent organ fibrosis in skin and lung

Persistent fibrosis in multiple organs is the hallmark of systemic sclerosis (SSc). Recent genetic and genomic studies implicate TLRs and their damage-associated molecular pattern (DAMP) endogenous ligands in fibrosis. To test the hypothesis that TLR4 and its coreceptor myeloid differentiation 2 (MD...

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Vydáno v:JCI Insight
Hlavní autoři: Bhattacharyya, Swati, Wang, Wenxia, Qin, Wenyi, Cheng, Kui, Coulup, Sara, Chavez, Sherry, Jiang, Shuangshang, Raparia, Kirtee, De Almeida, Lucia Maria V., Stehlik, Christian, Tamaki, Zenshiro, Yin, Hang, Varga, John
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124522/
https://ncbi.nlm.nih.gov/pubmed/29997297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.98850
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