TLR4-dependent fibroblast activation drives persistent organ fibrosis in skin and lung

Persistent fibrosis in multiple organs is the hallmark of systemic sclerosis (SSc). Recent genetic and genomic studies implicate TLRs and their damage-associated molecular pattern (DAMP) endogenous ligands in fibrosis. To test the hypothesis that TLR4 and its coreceptor myeloid differentiation 2 (MD...

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Dades bibliogràfiques
Publicat a:JCI Insight
Autors principals: Bhattacharyya, Swati, Wang, Wenxia, Qin, Wenyi, Cheng, Kui, Coulup, Sara, Chavez, Sherry, Jiang, Shuangshang, Raparia, Kirtee, De Almeida, Lucia Maria V., Stehlik, Christian, Tamaki, Zenshiro, Yin, Hang, Varga, John
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124522/
https://ncbi.nlm.nih.gov/pubmed/29997297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.98850
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