Exogenous LRRK2(G2019S) induces parkinsonian-like pathology in a nonhuman primate

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease among the elderly. To understand its pathogenesis and to test therapies, animal models that faithfully reproduce key pathological PD hallmarks are needed. As a prelude to developing a model of PD, we tested the tropism,...

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Vydáno v:JCI Insight
Hlavní autoři: Mestre-Francés, Nadine, Serratrice, Nicolas, Gennetier, Aurélie, Devau, Gina, Cobo, Sandra, Trouche, Stéphanie G., Fontès, Pascaline, Zussy, Charleine, De Deurwaerdere, Philippe, Salinas, Sara, Mennechet, Franck J.D., Dusonchet, Julien, Schneider, Bernard L., Saggio, Isabella, Kalatzis, Vasiliki, Luquin-Piudo, M. Rosario, Verdier, Jean-Michel, Kremer, Eric J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124435/
https://ncbi.nlm.nih.gov/pubmed/30046008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.98202
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