Exogenous LRRK2(G2019S) induces parkinsonian-like pathology in a nonhuman primate

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease among the elderly. To understand its pathogenesis and to test therapies, animal models that faithfully reproduce key pathological PD hallmarks are needed. As a prelude to developing a model of PD, we tested the tropism,...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Mestre-Francés, Nadine, Serratrice, Nicolas, Gennetier, Aurélie, Devau, Gina, Cobo, Sandra, Trouche, Stéphanie G., Fontès, Pascaline, Zussy, Charleine, De Deurwaerdere, Philippe, Salinas, Sara, Mennechet, Franck J.D., Dusonchet, Julien, Schneider, Bernard L., Saggio, Isabella, Kalatzis, Vasiliki, Luquin-Piudo, M. Rosario, Verdier, Jean-Michel, Kremer, Eric J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124435/
https://ncbi.nlm.nih.gov/pubmed/30046008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.98202
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