Exogenous LRRK2(G2019S) induces parkinsonian-like pathology in a nonhuman primate

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease among the elderly. To understand its pathogenesis and to test therapies, animal models that faithfully reproduce key pathological PD hallmarks are needed. As a prelude to developing a model of PD, we tested the tropism,...

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Publicado en:JCI Insight
Main Authors: Mestre-Francés, Nadine, Serratrice, Nicolas, Gennetier, Aurélie, Devau, Gina, Cobo, Sandra, Trouche, Stéphanie G., Fontès, Pascaline, Zussy, Charleine, De Deurwaerdere, Philippe, Salinas, Sara, Mennechet, Franck J.D., Dusonchet, Julien, Schneider, Bernard L., Saggio, Isabella, Kalatzis, Vasiliki, Luquin-Piudo, M. Rosario, Verdier, Jean-Michel, Kremer, Eric J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2018
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124435/
https://ncbi.nlm.nih.gov/pubmed/30046008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.98202
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