Sclerostin Antibody Treatment Stimulates Bone Formation to Normalize Bone Mass in Male Down Syndrome Mice

Down syndrome (DS), characterized by trisomy of human chromosome 21, is associated with a variety of endocrine disorders as well as profound skeletal abnormalities. The low bone mass phenotype in DS is defined by low bone turnover due to decreased osteoclast and osteoblast activity, decreasing the u...

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Detalhes bibliográficos
Publicado no:JBMR Plus
Main Authors: Williams, Diarra K, Parham, Sean G, Schryver, Eric, Akel, Nisreen S, Shelton, R Shane, Webber, Jessica, Swain, Francis L, Schmidt, Jami, Suva, Larry J, Gaddy, Dana
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124205/
https://ncbi.nlm.nih.gov/pubmed/30283889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbm4.10025
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