Sclerostin Antibody Treatment Stimulates Bone Formation to Normalize Bone Mass in Male Down Syndrome Mice

Down syndrome (DS), characterized by trisomy of human chromosome 21, is associated with a variety of endocrine disorders as well as profound skeletal abnormalities. The low bone mass phenotype in DS is defined by low bone turnover due to decreased osteoclast and osteoblast activity, decreasing the u...

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Publicat a:JBMR Plus
Autors principals: Williams, Diarra K, Parham, Sean G, Schryver, Eric, Akel, Nisreen S, Shelton, R Shane, Webber, Jessica, Swain, Francis L, Schmidt, Jami, Suva, Larry J, Gaddy, Dana
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
Matèries:
Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124205/
https://ncbi.nlm.nih.gov/pubmed/30283889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbm4.10025
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