Sclerostin Antibody Treatment Stimulates Bone Formation to Normalize Bone Mass in Male Down Syndrome Mice

Down syndrome (DS), characterized by trisomy of human chromosome 21, is associated with a variety of endocrine disorders as well as profound skeletal abnormalities. The low bone mass phenotype in DS is defined by low bone turnover due to decreased osteoclast and osteoblast activity, decreasing the u...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:JBMR Plus
Prif Awduron: Williams, Diarra K, Parham, Sean G, Schryver, Eric, Akel, Nisreen S, Shelton, R Shane, Webber, Jessica, Swain, Francis L, Schmidt, Jami, Suva, Larry J, Gaddy, Dana
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2017
Pynciau:
Original Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124205/
https://ncbi.nlm.nih.gov/pubmed/30283889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbm4.10025
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