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Conformational signatures in β-arrestin2 reveal natural biased agonism at a G-protein-coupled receptor

Discovery of biased ligands and receptor mutants allows characterization of G-protein- and β-arrestin-mediated signaling mechanisms of G-protein-coupled receptors (GPCRs). However, the structural mechanisms underlying biased agonism remain unclear for many GPCRs. We show that while Galanin induces t...

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Foilsithe in:Commun Biol
Main Authors: Reyes-Alcaraz, Arfaxad, Lee, Yoo-Na, Yun, Seongsik, Hwang, Jong-Ik, Seong, Jae Young
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6123711/
https://ncbi.nlm.nih.gov/pubmed/30272007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-018-0134-3
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