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Conformational signatures in β-arrestin2 reveal natural biased agonism at a G-protein-coupled receptor
Discovery of biased ligands and receptor mutants allows characterization of G-protein- and β-arrestin-mediated signaling mechanisms of G-protein-coupled receptors (GPCRs). However, the structural mechanisms underlying biased agonism remain unclear for many GPCRs. We show that while Galanin induces t...
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| Udgivet i: | Commun Biol |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6123711/ https://ncbi.nlm.nih.gov/pubmed/30272007 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-018-0134-3 |
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