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Role of Interstitial Fluid Turnover on Target Suppression by Therapeutic Biologics Using a Minimal Physiologically Based Pharmacokinetic Model
For therapeutic biologics against soluble ligands, the magnitude and duration of target suppression affect their therapeutic efficacy. Many factors have been evaluated in relation to target suppression but the interstitial fluid turnover rate in target tissues has not been considered. Inspired by th...
সংরক্ষণ করুন:
| প্রকাশিত: | J Pharmacol Exp Ther |
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| প্রধান লেখক: | , , |
| বিন্যাস: | Artigo |
| ভাষা: | Inglês |
| প্রকাশিত: |
The American Society for Pharmacology and Experimental Therapeutics
2018
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6123664/ https://ncbi.nlm.nih.gov/pubmed/30002096 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.118.250134 |
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