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Across-Species Scaling of Monoclonal Antibody Pharmacokinetics Using a Minimal PBPK Model
PURPOSE: To examine the across-species scalability of monoclonal antibody (mAb) pharmacokinetics (PK) and assess similarities in tissue distribution across species using a recently developed minimal PBPK (mPBPK) model. METHODS: Twelve sets of antibody PK data from various species were obtained from...
Tallennettuna:
| Julkaisussa: | Pharm Res |
|---|---|
| Päätekijät: | , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2015
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4580522/ https://ncbi.nlm.nih.gov/pubmed/25939552 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-015-1703-5 |
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