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mTORC1 impedes osteoclast differentiation via calcineurin and NFATc1

Rapamycins are immunosuppressant and anti-cancer drugs that inhibit the kinase mTOR. Clinically, they often cause bone pain, bone necrosis, and high bone turnover, yet the mechanisms are unclear. Here we show that mTORC1 activity is high in osteoclast precursors but downregulated upon RANKL treatmen...

詳細記述

保存先:
書誌詳細
出版年:Commun Biol
主要な著者: Huynh, HoangDinh, Wan, Yihong
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6123628/
https://ncbi.nlm.nih.gov/pubmed/30271915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-018-0028-4
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