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New insights into RAS biology reinvigorate interest in mathematical modeling of RAS signaling

RAS is the most frequently mutated gene across human cancers, but developing inhibitors of mutant RAS has proven to be challenging. Given the difficulties of targeting RAS directly, drugs that impact the other components of pathways where mutant RAS operates may potentially be effective. However, th...

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Bibliographic Details
Published in:Semin Cancer Biol
Main Authors: Erickson, Keesha E., Rukhlenko, Oleksii S., Posner, Richard G., Hlavacek, William S., Kholodenko, Boris N.
Format: Artigo
Language:Inglês
Published: 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6123307/
https://ncbi.nlm.nih.gov/pubmed/29518522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semcancer.2018.02.008
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