Modeling cell line-specific recruitment of signaling proteins to the insulin-like growth factor 1 receptor

Receptor tyrosine kinases (RTKs) typically contain multiple autophosphorylation sites in their cytoplasmic domains. Once activated, these autophosphorylation sites can recruit downstream signaling proteins containing Src homology 2 (SH2) and phosphotyrosine-binding (PTB) domains, which recognize pho...

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Bibliografiske detaljer
Udgivet i:PLoS Comput Biol
Main Authors: Erickson, Keesha E., Rukhlenko, Oleksii S., Shahinuzzaman, Md, Slavkova, Kalina P., Lin, Yen Ting, Suderman, Ryan, Stites, Edward C., Anghel, Marian, Posner, Richard G., Barua, Dipak, Kholodenko, Boris N., Hlavacek, William S.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6353226/
https://ncbi.nlm.nih.gov/pubmed/30653502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1006706
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