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A systematic analysis of signaling reactivation and drug resistance

Increasing evidence suggests that the reactivation of initially inhibited signaling pathways causes drug resistance. Here, we analyze how network topologies affect signaling responses to drug treatment. Network-dependent drug resistance is commonly attributed to negative and positive feedback loops....

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Bibliographic Details
Published in:Cell Rep
Main Authors: Kholodenko, Boris N., Rauch, Nora, Kolch, Walter, Rukhlenko, Oleksii S.
Format: Artigo
Language:Inglês
Published: 2021
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8202068/
https://ncbi.nlm.nih.gov/pubmed/34038718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.109157
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