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Src activation by Chk1 promotes actin patch formation and prevents chromatin bridge breakage in cytokinesis

In cytokinesis with chromatin bridges, cells delay abscission and retain actin patches at the intercellular canal to prevent chromosome breakage. In this study, we show that inhibition of Src, a protein-tyrosine kinase that regulates actin dynamics, or Chk1 kinase correlates with chromatin breakage...

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Podrobná bibliografie
Vydáno v:J Cell Biol
Hlavní autoři: Dandoulaki, Maria, Petsalaki, Eleni, Sumpton, David, Zanivan, Sara, Zachos, George
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6122982/
https://ncbi.nlm.nih.gov/pubmed/29954829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201802102
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