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Chk2 prevents mitotic exit when the majority of kinetochores are unattached

The spindle checkpoint delays exit from mitosis in cells with spindle defects. In this paper, we show that Chk2 is required to delay anaphase onset when microtubules are completely depolymerized but not in the presence of relatively few unattached kinetochores. Mitotic exit in Chk2-deficient cells c...

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Hlavní autoři: Petsalaki, Eleni, Zachos, George
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018780/
https://ncbi.nlm.nih.gov/pubmed/24798733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201310071
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