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Ascorbate oxidation by Cu(Amyloid-β) complexes: determination of the intrinsic rate as function of alterations in the peptide sequence reveals key residues for ROS production
Along with aggregation of the amyloid-β (Aβ) peptide and subsequent deposit of amyloid plaques, oxidative stress is an important feature in Alzheimer’s disease. Cu bound to Aβ is able to produce Reactive Oxygen Species (ROS) by the successive reductions of molecular dioxygen and the ROS such produce...
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| Опубликовано в: : | Anal Chem |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6120677/ https://ncbi.nlm.nih.gov/pubmed/29611698 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.8b00740 |
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