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Ascorbate oxidation by Cu(Amyloid-β) complexes: determination of the intrinsic rate as function of alterations in the peptide sequence reveals key residues for ROS production

Along with aggregation of the amyloid-β (Aβ) peptide and subsequent deposit of amyloid plaques, oxidative stress is an important feature in Alzheimer’s disease. Cu bound to Aβ is able to produce Reactive Oxygen Species (ROS) by the successive reductions of molecular dioxygen and the ROS such produce...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Anal Chem
Päätekijät: Atrián-Blasco, Elena, del Barrio, Melisa, Faller, Peter, Hureau, Christelle
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2018
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6120677/
https://ncbi.nlm.nih.gov/pubmed/29611698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.8b00740
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