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Identification of key structural features of the elusive Cu–Aβ complex that generates ROS in Alzheimer’s disease
Oxidative stress is linked to the etiology of Alzheimer’s disease (AD), the most common cause of dementia in the elderly. Redox active metal ions such as copper catalyze the production of Reactive Oxygen Species (ROS) when bound to the amyloid-β (Aβ) peptide encountered in AD. We propose that this r...
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| Publicado no: | Chem Sci |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Royal Society of Chemistry
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5613283/ https://ncbi.nlm.nih.gov/pubmed/28970897 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc00809k |
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