Genetic instability and recurrent MYC amplification in ALK‐translocated NSCLC: a central role of TP53 mutations

The anaplastic lymphoma kinase (ALK) rearrangement defines a distinct molecular subtype of non‐small cell lung cancer (NSCLC). Despite the excellent initial efficacy of ALK inhibitors in patients with ALK+ lung cancer, resistance occurs almost inevitably. To date, there is no reliable biomarker allo...

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Bibliografski detalji
Izdano u:J Pathol
Glavni autori: Alidousty, Christina, Baar, Till, Martelotto, Luciano G, Heydt, Carina, Wagener, Svenja, Fassunke, Jana, Duerbaum, Nicolai, Scheel, Andreas H, Frank, Sandra, Holz, Barbara, Binot, Elke, Kron, Anna, Merkelbach‐Bruse, Sabine, Ihle, Michaela A, Wolf, Jürgen, Buettner, Reinhard, Schultheis, Anne Maria
Format: Artigo
Jezik:Inglês
Izdano: John Wiley & Sons, Ltd 2018
Teme:
Original Papers
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6120547/
https://ncbi.nlm.nih.gov/pubmed/29885057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.5110
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