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Mutational spectrum of acquired resistance to reversible versus irreversible EGFR tyrosine kinase inhibitors
BACKGROUND: Over the past years, EGFR tyrosine kinase inhibitors (TKI) revolutionized treatment response. 1st-generation (reversible) EGFR TKI and later the 2nd –generation irreversible EGFR TKI Afatinib were aimed to improve treatment response. Nevertheless, diverse resistance mechanisms develop wi...
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| Опубликовано в: : | BMC Cancer |
|---|---|
| Главные авторы: | , , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BioMed Central
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7216404/ https://ncbi.nlm.nih.gov/pubmed/32397977 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-020-06920-3 |
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