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An oxanthroquinone derivative that disrupts RAS plasma membrane localization inhibits cancer cell growth
Oncogenic RAS proteins are commonly expressed in human cancer. To be functional, RAS proteins must undergo post-translational modification and localize to the plasma membrane (PM). Therefore, compounds that prevent RAS PM targeting have potential as putative RAS inhibitors. Here we examine the mecha...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6120197/ https://ncbi.nlm.nih.gov/pubmed/29970615 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003907 |
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