Activation of Smoothened in the Hedgehog pathway unexpectedly increases Gα(s)-dependent cAMP levels in Drosophila

Hedgehog (Hh) signaling plays a key role in the development and maintenance of animal tissues. This signaling is mediated by the atypical G protein–coupled receptor (GPCR) Smoothened (Smo). Smo activation leads to signaling through several well-characterized effectors to activate Hh target gene expr...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Praktiknjo, Samantha D., Saad, Farah, Maier, Dominic, Ip, Pamela, Hipfner, David R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6120187/
https://ncbi.nlm.nih.gov/pubmed/30018136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.001953
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