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An intracellular activation of Smoothened that is independent of Hedgehog stimulation in Drosophila
Smoothened (Smo), a GPCR family protein, plays a critical role in the reception and transduction of Hedgehog (Hh) signal. Smo is phosphorylated and activated on the cell surface; however, it is unknown whether Smo can be intracellularly activated. Here, we demonstrate that inactivation of the ESCRT-...
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| Udgivet i: | J Cell Sci |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Company of Biologists Ltd
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5818065/ https://ncbi.nlm.nih.gov/pubmed/29142103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.211367 |
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