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An intracellular activation of Smoothened that is independent of Hedgehog stimulation in Drosophila
Smoothened (Smo), a GPCR family protein, plays a critical role in the reception and transduction of Hedgehog (Hh) signal. Smo is phosphorylated and activated on the cell surface; however, it is unknown whether Smo can be intracellularly activated. Here, we demonstrate that inactivation of the ESCRT-...
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| Publicado en: | J Cell Sci |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The Company of Biologists Ltd
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5818065/ https://ncbi.nlm.nih.gov/pubmed/29142103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.211367 |
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