Intravenously Injected Amyloid-β Peptide With Isomerized Asp7 and Phosphorylated Ser8 Residues Inhibits Cerebral β-Amyloidosis in AβPP/PS1 Transgenic Mice Model of Alzheimer’s Disease

Cerebral β-amyloidosis, an accumulation in the patient’s brain of aggregated amyloid-β (Aβ) peptides abnormally saturated by divalent biometal ions, is one of the hallmarks of Alzheimer’s disease (AD). Earlier, we found that exogenously administrated synthetic Aβ with isomerized Asp7 (isoD7-Aβ) indu...

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Detalles Bibliográficos
Publicado en:Front Neurosci
Main Authors: Kozin, Sergey A., Barykin, Evgeny P., Telegin, Georgy B., Chernov, Alexander S., Adzhubei, Alexei A., Radko, Sergey P., Mitkevich, Vladimir A., Makarov, Alexander A.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2018
Assuntos:
Neuroscience
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6119768/
https://ncbi.nlm.nih.gov/pubmed/30210271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2018.00518
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