Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that is extremely refractory to the therapeutic approaches that have been evaluated to date. Recently, it has been demonstrated that PDAC tumors are dependent upon a metabolic pathway involving aspartate aminotransferase 1, also known as...

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Publicado en:Bioorg Med Chem Lett
Main Authors: Anglin, Justin, Zavareh, Reza Beheshti, Sander, Philipp N., Haldar, Daniel, Mullarky, Edouard, Cantley, Lewis C., Kimmelman, Alec C., Lyssiotis, Costas A., Lairson, Luke L.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6119644/
https://ncbi.nlm.nih.gov/pubmed/29731362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.04.061
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