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Discovery of small molecules for the reversal of T cell exhaustion

Inhibitory receptors (IR) function as critical regulators of immune responses by tempering T cell activity. In humans, several persisting viruses as well as cancers exploit IR signaling by upregulating IR ligands, resulting in suppression of T cell function (i.e., exhaustion). This allows escape fro...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Marro, Brett S., Zak, Jaroslav, Zavareh, Reza Beheshti, Teijaro, John R., Lairson, Luke L., Oldstone, Michael B.A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6931400/
https://ncbi.nlm.nih.gov/pubmed/31801090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.10.119
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