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Discovery of small molecules for the reversal of T cell exhaustion
Inhibitory receptors (IR) function as critical regulators of immune responses by tempering T cell activity. In humans, several persisting viruses as well as cancers exploit IR signaling by upregulating IR ligands, resulting in suppression of T cell function (i.e., exhaustion). This allows escape fro...
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| Publicado en: | Cell Rep |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6931400/ https://ncbi.nlm.nih.gov/pubmed/31801090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.10.119 |
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