Use of the PET ligand florbetapir for in vivo imaging of pancreatic islet amyloid deposits in human islet amyloid polypeptide transgenic mice

AIMS/HYPOTHESIS: Islet amyloid deposits contribute to beta cell dysfunction and death in the majority of individuals with type 2 diabetes, but non-invasive methods to determine the presence of these pathological protein aggregates are currently not available. Therefore, we determined whether florbet...

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Detalhes bibliográficos
Publicado no:Diabetologia
Main Authors: Templin, Andrew T., Meier, Daniel T., Willard, Joshua R., Wolden-Hanson, Tami, Conway, Kelly, Lin, Yin-Guo, Gillespie, Patrick J., Bokvist, Krister B., Attardo, Giorgio, Kahn, Steven E., Scheuner, Donalyn, Hull, Rebecca L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6119478/
https://ncbi.nlm.nih.gov/pubmed/30046852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-018-4695-y
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