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Exendin-4 increases islet amyloid deposition but offsets the resultant beta-cell toxicity in human islet amyloid polypeptide transgenic mouse islets
AIMS/HYPOTHESIS: In type 2 diabetes, aggregation of islet amyloid polypeptide (IAPP) into amyloid is associated with beta-cell loss. As IAPP is co-secreted with insulin, we hypothesised that IAPP secretion is necessary for amyloid formation, and treatments which increase insulin (and IAPP) secretion...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3220951/ https://ncbi.nlm.nih.gov/pubmed/21484213 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-011-2143-3 |
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