Neuropilin-1 upregulation elicits adaptive resistance to oncogene-targeted therapies

Cancer cell dependence on activated oncogenes is therapeutically targeted, but acquired resistance is virtually unavoidable. Here we show that the treatment of addicted melanoma cells with BRAF inhibitors, and of breast cancer cells with HER2-targeted drugs, led to an adaptive rise in neuropilin-1 (...

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Dettagli Bibliografici
Pubblicato in:J Clin Invest
Autori principali: Rizzolio, Sabrina, Cagnoni, Gabriella, Battistini, Chiara, Bonelli, Stefano, Isella, Claudio, Van Ginderachter, Jo A., Bernards, René, Di Nicolantonio, Federica, Giordano, Silvia, Tamagnone, Luca
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6118581/
https://ncbi.nlm.nih.gov/pubmed/29953416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI99257
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