Neuropilin-1 upregulation elicits adaptive resistance to oncogene-targeted therapies

Cancer cell dependence on activated oncogenes is therapeutically targeted, but acquired resistance is virtually unavoidable. Here we show that the treatment of addicted melanoma cells with BRAF inhibitors, and of breast cancer cells with HER2-targeted drugs, led to an adaptive rise in neuropilin-1 (...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Rizzolio, Sabrina, Cagnoni, Gabriella, Battistini, Chiara, Bonelli, Stefano, Isella, Claudio, Van Ginderachter, Jo A., Bernards, René, Di Nicolantonio, Federica, Giordano, Silvia, Tamagnone, Luca
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6118581/
https://ncbi.nlm.nih.gov/pubmed/29953416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI99257
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados