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Hgf/Met activation mediates resistance to BRAF inhibition in murine anaplastic thyroid cancers
Anaplastic thyroid carcinomas (ATCs) have a high prevalence of BRAF and TP53 mutations. A trial of vemurafenib in nonmelanoma BRAF(V600E)-mutant cancers showed significant, although short-lived, responses in ATCs, indicating that these virulent tumors remain addicted to BRAF despite their high mutat...
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| Publicado no: | J Clin Invest |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6118575/ https://ncbi.nlm.nih.gov/pubmed/29990309 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI120966 |
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