Berberine Reduces Pyruvate-driven Hepatic Glucose Production by Limiting Mitochondrial Import of Pyruvate through Mitochondrial Pyruvate Carrier 1

BACKGROUND: Mitochondrial pyruvate import via mitochondrial pyruvate carrier (MPC) is a central step in hepatic gluconeogenesis. Berberine inhibits hepatic gluconeogenesis, but the mechanism is incompletely understood. This study aims to investigate whether berberine could reduce excessive hepatic g...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Li, Aiyun, Liu, Qun, Li, Qiang, Liu, Baolin, Yang, Yang, Zhang, Ning
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6117739/
https://ncbi.nlm.nih.gov/pubmed/30093307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.07.039
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