An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion

OBJECTIVE: Transport of pyruvate into the mitochondrial matrix by the Mitochondrial Pyruvate Carrier (MPC) is an important and rate-limiting step in its metabolism. In pancreatic β-cells, mitochondrial pyruvate metabolism is thought to be important for glucose sensing and glucose-stimulated insulin...

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Dettagli Bibliografici
Pubblicato in:Mol Metab
Autori principali: McCommis, Kyle S., Hodges, Wesley T., Bricker, Daniel K., Wisidagama, Dona R., Compan, Vincent, Remedi, Maria S., Thummel, Carl S., Finck, Brian N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2016
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021712/
https://ncbi.nlm.nih.gov/pubmed/27656398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2016.06.016
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