SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue

SERINC5 is a host restriction factor that impairs infectivity of HIV-1 and other primate lentiviruses and is counteracted by the viral accessory protein Nef. However, the importance of SERINC5 antagonism for viral replication and cytopathicity remained unclear. Here, we show that the Nef protein of...

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Udgivet i:PLoS Pathog
Main Authors: Kmiec, Dorota, Akbil, Bengisu, Ananth, Swetha, Hotter, Dominik, Sparrer, Konstantin M. J., Stürzel, Christina M., Trautz, Birthe, Ayouba, Ahidjo, Peeters, Martine, Yao, Zhong, Stagljar, Igor, Passos, Vânia, Zillinger, Thomas, Goffinet, Christine, Sauter, Daniel, Fackler, Oliver T., Kirchhoff, Frank
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6117100/
https://ncbi.nlm.nih.gov/pubmed/30125328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007269
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