The Antagonism of HIV-1 Nef to SERINC5 Particle Infectivity Restriction Involves the Counteraction of Virion-Associated Pools of the Restriction Factor

SERINC3 (serine incorporator 3) and SERINC5 are recently identified host cell inhibitors of HIV-1 particle infectivity that are counteracted by the viral pathogenesis factor Nef. Here we confirm that HIV-1 Nef, but not HIV-1 Vpu, antagonizes the particle infectivity restriction of SERINC5. SERINC5 a...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Virol
Prif Awduron: Trautz, Birthe, Pierini, Virginia, Wombacher, Rebecka, Stolp, Bettina, Chase, Amanda J., Pizzato, Massimo, Fackler, Oliver T.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2016
Pynciau:
Virus-Cell Interactions
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5110172/
https://ncbi.nlm.nih.gov/pubmed/27681140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01246-16
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