The host-cell restriction factor SERINC5 restricts HIV-1 infectivity without altering the lipid composition and organization of viral particles

The host-cell restriction factor SERINC5 potently suppresses the infectivity of HIV, type 1 (HIV-1) particles, and is counteracted by the viral pathogenesis factor Nef. However, the molecular mechanism by which SERINC5 restricts HIV-1 particle infectivity is still unclear. Because SERINC proteins ha...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Trautz, Birthe, Wiedemann, Hannah, Lüchtenborg, Christian, Pierini, Virginia, Kranich, Jan, Glass, Bärbel, Kräusslich, Hans-Georg, Brocker, Thomas, Pizzato, Massimo, Ruggieri, Alessia, Brügger, Britta, Fackler, Oliver T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5566525/
https://ncbi.nlm.nih.gov/pubmed/28659343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.797332
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