Immune complexes containing scleroderma-specific autoantibodies induce a profibrotic and proinflammatory phenotype in skin fibroblasts

BACKGROUND: In systemic sclerosis (SSc), autoantibodies provide the most accurate tool to predict the disease subset and pattern of organ involvement. Scleroderma autoantibodies target nucleic acids or DNA/RNA-binding proteins, thus SSc immune complexes (ICs) can embed nucleic acids. Our working hyp...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Raschi, Elena, Chighizola, Cecilia Beatrice, Cesana, Laura, Privitera, Daniela, Ingegnoli, Francesca, Mastaglio, Claudio, Meroni, Pier Luigi, Borghi, Maria Orietta
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6116570/
https://ncbi.nlm.nih.gov/pubmed/30157947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-018-1689-6
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