Scleroderma-specific autoantibodies embedded in immune complexes mediate endothelial damage: an early event in the pathogenesis of systemic sclerosis

BACKGROUND: Consistently with their diagnostic and prognostic value, autoantibodies specific for systemic sclerosis (SSc) embedded in immune complexes (ICs) elicited a pro-inflammatory and pro-fibrotic cascade in healthy skin fibroblasts, engaging Toll-like receptors (TLRs) via their nucleic acid co...

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Pubblicato in:Arthritis Res Ther
Autori principali: Raschi, Elena, Privitera, Daniela, Bodio, Caterina, Lonati, Paola Adele, Borghi, Maria Orietta, Ingegnoli, Francesca, Meroni, Pier Luigi, Chighizola, Cecilia Beatrice
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7654597/
https://ncbi.nlm.nih.gov/pubmed/33168071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-020-02360-3
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