Pathogenic Role of Complement in Antiphospholipid Syndrome and Therapeutic Implications

Antiphospholipid syndrome (APS) is an acquired autoimmune disease characterized by thromboembolic events, pregnancy morbidity, and the presence of antiphospholipid (aPL) antibodies. There is sound evidence that aPL act as pathogenic autoantibodies being responsible for vascular clots and miscarriage...

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Detalhes bibliográficos
Main Authors: Francesco Tedesco, Maria Orietta Borghi, Maria Gerosa, Cecilia Beatrice Chighizola, Paolo Macor, Paola Adele Lonati, Alessandro Gulino, Beatrice Belmonte, Pier Luigi Meroni
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018-06-01
Colecção:Frontiers in Immunology
Assuntos:
complement
antiphospholipid syndrome
anti-beta2 glycoprotein I antibodies
thrombosis
miscarriages
animal models
Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2018.01388/full
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