Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism

Activation of macrophages by inflammatory stimuli induces reprogramming of mitochondrial metabolism to support the production of pro-inflammatory cytokines and nitric oxide. Hallmarks of this metabolic rewiring are downregulation of α-ketoglutarate formation by isocitrate dehydrogenase (IDH) and acc...

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Vydáno v:Cell Rep
Hlavní autoři: Koenis, Duco Steven, Medzikovic, Lejla, van Loenen, Pieter Bas, van Weeghel, Michel, Huveneers, Stephan, Vos, Mariska, Evers-van Gogh, Ingrid Johanna, Van den Bossche, Jan, Speijer, Dave, Kim, Yongsoo, Wessels, Lodewyk, Zelcer, Noam, Zwart, Wilbert, Kalkhoven, Eric, de Vries, Carlie Jacoba
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6113932/
https://ncbi.nlm.nih.gov/pubmed/30134173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.07.065
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